Levine-Tiefenbrun, M. et al. Nasal sprays may be a promising first line of defense against SARS-CoV-2 infection. The trial medication (placebo nasal spray, 0.02% azelastine nasal spray or 0.1% azelastine nasal spray (the latter being identically composed as the commercial anti-allergic product Pollival) was manufactured at URSAPHARM Arzneimittel GmbH, Saarbruecken, Germany). Ann. Emerg. Patients were assigned a treatment number in an ascending mode according to their chronological order of inclusion. A newly discovered small molecule could be sprayed into people's noses to prevent COVID-19 illness prior to exposure and provide early treatment if administered soon after infection, according to a study in mice led by Cornell researchers. Res. Ninety SARS-CoV-2 positive patients were randomized into 3 groups receiving placebo, 0.02% or 0.1% azelastine nasal spray for 11days, during which viral loads were assessed by quantitative PCR. The antiviral also could offer an alternative to people who cannot or do not respond to a vaccine. WebMD does not provide medical advice, diagnosis or treatment. SRT was originally developed in 2009 by Dr. Thomas Hummel at the University of Dresden. https://cornellsun.com/2022/04/27/cornell-research-team-to-develop-covid-19-nose-spray-treatment/, https://doi.org/10.1038/s41586-022-04661-w, Antiviral Nasal Spray Shows Promise Fighting COVID-19. Elife 10, e69302. The study was termed CARVIN (referring to COVID-19: Azelastine nasal spray Reduces Virus-load In Nasal swabs). Ghahremanpour et al. This was a prospective, randomized, double-blind, placebo-controlled dose-finding proof-of-concept study, in which azelastine nasal spray was used in 2 doses: the commercially available concentration of 0.1% and a fivefold lower concentration of 0.02%. Chem. At the end of the study (day 60), all except one single patient (placebo group) showed a score of 0. TMPRSS2 is a protein in mouse and human cells that SARS-CoV-2 uses as a gateway to infect humans. J. CofixRx, LLC - 626860 - 04/05/2022 | FDA Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. FH is the CEO of URSAPHARM Arzneimittel GmbH. were investigators involved in the conduct of the study. J. For clarity reason, only cp/mL values of the ORF 1a/b gene are shown in the main text of the manuscript. It would be desirable to study azelastine treatment in a greater COVID-19 population to get further insights on azelastines effects on individual symptoms and to determine its potential on long-term symptoms. and F.H. Nasal Sprays Could Protect You From Serious COVID-19 Illness The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. A complete list of inclusion and exclusion criteria is presented in Table 1. Overall, no significant differences were observed between treatment groups regarding gender, age and body mass index (bmi, supplementary Table S1). Samples of day 1 represent pre-treatment baseline samples. The sample size calculation was based on the expected reduction of virus load during the treatment considering 3 treatment arms. https://doi.org/10.1038/s41591-021-01316-7 (2021). Importantly, the AUC analysis depicting the viral load decrease based on the detection of the ORF 1a/b gene over the 11-day treatment period showed a significantly greater reduction of virus load in the 0.1% azelastine group compared to placebo. Approval of the study by the German Federal Institute for Drugs and Medical Devices (BfArM) was given on 3rd February 2021. Thus, a nitric oxide nasal spray was shown to reduce the viral load in adult patients with mild COVID-19 infection, and an accelerated SARS-CoV-2 clearance compared to placebo was demonstrated18. For male patients, the assessment was done via phone call. Following translocation from nucleus to the endoplasmic reticulum (ER), the sigma-1 receptor (among other factors) plays a role in viral replication. It should be noted that the SARS-CoV-2 alpha variant (B.1.1.7) was the dominant variant in Germany during the enrolment phase of the current study16. It's being studied as a potential way to prevent mild to moderate cases of COVID-19. Of note, we cannot rule out the possibility that the placebo (nasal spray buffer) contributed to viral clearance. With the changing epidemiology of COVID-19 and its impact on our daily lives, there is still an unmet need of COVID-19 therapies treating early infections to prevent progression. The data that support the findings of this study are available from URSAPHARM Arzneimittel GmbH but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Could a nose spray a day keep COVID away? - nature.com Lett. Rev. Symptoms were documented in patient diaries. 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Vitiello, A., Ferrara, F., Troiano, V. & La Porta, R. COVID-19 vaccines and decreased transmission of SARS-CoV-2. Small differences were found with regard to age and bmi, which were both slightly higher in the azelastine 0.1% group (supplementary Table S1). Cornell Daily Sun. ISSN 1476-4687 (online) If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Multinomial regression analysis was done to 26 determine the association between nasal carriage of Bacillus and COVID-19 severity after 27 adjusting for age, sex, and co-morbidity status. Our study population was characterized by an initial mean viral load of log10 6.851.31cp/mL, which was higher than more recently reported SARS-CoV-2 viral load values26. Slider with three articles shown per slide. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Because we get infected with SARS-CoV-2 primarily by breathing it in, a nasal spray might be an easy and efficient way to offer protection against the virus, especially in crowded places. Researchers have looked for ways to prevent SARS-CoV-2 infection that the virus cant learn to dodge or evade by mutating. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. 62, 50937, Cologne, Germany, Medical Faculty, Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Kerpener Str. During visits, nasopharyngeal swabs were taken for quantitative PCR measurements, and investigators assessed the patient status in accordance with the WHO clinical progression scale11. 2 and supplementary Table S2). Researchers are developing coronavirus vaccines that will be sprayed up the nose. Bioinformation 16, 236244. Boots nasal spray could help fight COVID-19, new study finds Coronavirus: how to protect yourself and others, plus what - Which? 24 COVID-19 status classified as negative, asymptomatic, mild, or severe.
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