Amidst coronavirus outbreak, thalassemics are facing blood shortage concerns. Acta Biomed. Vaccination can help prevent COVID-19 infection and prevent severe illness if you do. Some genes contribute to the alpha chain, while others contribute to the beta chain. People with beta thalassemia minor might never know they have the disease. Future Sci OA. Vaccines can help people with beta thalassemia lower their chances of getting COVID-19 or having severe illness if they do get COVID-19. According to this systematic-review meta-analysis, beta-thalassemia carriers could be less affected by CO VID-19 than the general population and more susceptible to die from COVID-19 or one of its consequences. Regardless of if a specific blood type is associated with a greater risk of contracting COVID-19 and developing severe disease, keep in mind that many other factors, such as age or existing health conditions, are likely to play a larger, dominant role in determining personal risk from COVID-19. Nicosia, Cyprus: Thalassaemia International Federation; 2014. Blood banking and transfusion medicine challenges during the COVID-19 pandemic. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Ruangvutilert P, et al. They also shouldnt get it if they have a known allergy to a component of the vaccine. National Library of Medicine Vaccines & immunizations: Use of COVID-19 vaccines in the U.S. (2022). Impaired immune cell . 2023 Feb 9;10:1056599. doi: 10.3389/fmed.2023.1056599. eCollection 2022 Aug. See this image and copyright information in PMC. Commentary: Could iron chelators prove to be useful as an adjunct to COVID-19 Treatment Regimens? Thalassemias. The need for frequent blood transfusions and complications of the disease that result in more clinic visits and hospitalizations could raise the odds that someone would come into contact with the virus. chenevex, France. You likely wont have any symptoms. Karimi M, Haghpanah S, Zarei T, et al. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Thalassemia may cause you to experience anemia-like symptoms that range from mild to severe. COVID Natural Immunity: What You Need to Know Lansiaux E, et al. This means red blood cells aren't made properly or they are destroyed. The current evidence suggests that the benefits of COVID-19 vaccination outweigh the risk of side effects for most people with autoimmune disease, according to the Global Autoimmune Institute, which reviewed the available scientific literature. And while some people develop more severe forms of COVID-19, others develop mild or no symptoms. People with thalassemia tend to experience similar complications from COVID-19 as those without thalassemia. (2022). If you have one unaffected gene, it mostly overrides the faulty gene. Thalassemia is a blood disorder in which the body makes an abnormal form of hemoglobin. The site is secure. Therefore, it is unknown if COVID-19 vaccines are as efficacious for patients with thalassemia as they were found to be for the clinical trial participants . That said, the shortage of the blood supply has proven challenging. The prevalence among those who were transfusion dependent was roughly the same as people without thalassemia. Treatment is with corticosteroids. doi:10.1002/ajh.25857, NGO A, Masel D, Cahill C, Blumberg N, Refaiie MA. If the mutation affects two genes, you have alpha-thalassemia minor. Epub 2020 Sep 15. Some studies estimate the worldwide prevalence of alpha-thalassemia trait to be as high as 5%. Exemptions may be granted for people with severe allergies to COVID-19 vaccines or any of their components. COVID vaccine & autoimmune disease FAQ. HHS Vulnerability Disclosure, Help (2022). While Health is trying to keep our stories as up-to-date as possible, we also encourage readers to stay informed on news and recommendations for their own communities by using the CDC, WHO, and their local public health department as resources. Still, you can pass on the disease to your child. It's been found that, in general, people who have COVID-19 often have significantly reduced hemoglobin levels, especially with severe disease. You can still pass on the affected gene, but you wont experience any symptoms. COVID19 in a pregnant patient with betathalassemia major: A case Bender MA, et al. Immune responses in beta-thalassaemia: heme - Scientific Reports If both parents carry a trait for either alpha- or beta-thalassemia, their child could develop a severe form of the disease. These findings may be due to statistical randomness because of the small sample size. Vitamin and mineral supplementation for -thalassemia during COVID-19 pandemic. doi: 10.1002/ccr3.6114. A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. Researchers found no link between blood type and COVID-19 risk, adding that more research was needed on the topic. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Beta-thalassemia causes symptoms related to anemia, including weak or brittle bones, and leads to problems with how your bones develop. The third group includes people with Thalassemia minor, who have mild anaemia only. The causal virus behind this disease, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), conceivably attacks the . Thus far, studies have been mixed as to whether thalassemia patients are more likely to experience serious outcomes of COVID-19 (such as hospitalization or death). Metabolism. The .gov means its official. Management of Hemoglobin Disorders During the COVID-19 Pandemic Thalassemia trait, aka thalassemia minor, usually doesnt cause health issues. Blood type has been identified as a risk factor in many diseases, from cancer to venous and arterial thromboembolism. The most important thing you can do is make sure you are vaccinated and stay up to date on when boosters are needed. A Practical Approach to the Management of Cancer Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic: An International Collaborative Group. COVID-19 pandemic and care of transfusion-dependent patients of thalassaemia: Experience from a paediatric centre in North India. Blood clots are fairly common with COVID-19, and many physicians view it as a disease of blood vessels. 2023 Jan 1;15(1):e2023007. You'll likely need several tests by different doctors. A comprehensive update of ICET-A Network on COVID-19 in thalassemias: what we know and where we stand. Beta-Thalassemia minor and SARS-CoV-2, prevalence, severity, morbidity Published 2020 Sep 7. doi:10.23750/abm.v91i3.10063. Keywords: A protein called the Rh factor can also be present (+) or absent (-) from the blood. In general, people with severe diseases are at a higher risk from COVID-19. The results provide hope that people receiving SARS-CoV-2 vaccines will develop similar lasting immune memories after vaccination. But again, experts say it's too early to know for sure. Hemoglobin is the component of red blood cells that carries oxygen to the tissues of the body. Chowdhury SF, Anwar S. Management of hemoglobin disorders during the COVID-19 pandemic. Learn more. There are very few medications that are contraindicated (should not be used) in people who may be exposed to SARS-CoV-2 or who have developed a COVID-19 infection. Sadly, the reduction in the blood supply has led many people with thalassemia to receive fewer transfusions than usual, prompting healthcare providers caring for people with the condition to look for options that may reduce the need for or frequency of transfusions. Vaccination is particularly important for people with cardiovascular disease because theyre more likely to develop severe complications from COVID-19 infection. If the inherited mutation affects only one gene, you have beta-thalassemia minor. According to this systematic-review meta-analysis, beta-thalassemia carriers could be less affected by CO VID-19 than the general population and more susceptible to die from COVID-19 or one of its consequences. I declare no competing interests. EHA and TIF explore how COVID-19 is affecting thalassemia and SCD patients. Bender MA, et al. See additional information. If you have thalassemia trait, it means you carry a genetic mutation that causes thalassemia, but you dont have the disease yourself. Should you get a COVID vaccine if you have beta thalassemia? While there are no specific guidelines at this time, some researchers believe that hemoglobin levels should be monitored closely in people with thalassemia if they develop COVID-19, even when symptoms are only mild. Our website services, content, and products are for informational purposes only. Lasting immunity found after recovery from COVID-19 Some people have been re-infected multiple times with the virus, while others appear to have avoided the virus entirely. As thalassemia is considered to be a severe underlying medical condition , both adults and children with thalassemia were excluded from the COVID-19 vaccine clinical trials. Although epidemiologic evidence concerning the novel coronavirus (SARS-CoV-2) infection in these patients is currently lacking, the COVID-19 pandemic represents a significant challenge for . See additional information. But such tests are often costly. And people with some blood disorders like sickle cell disease are resistant to malaria, added Dr. Adalja. The coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has become a global public health concern after being first reported in China and has subsequently spread worldwide. A Study Says These 4 Factors May Predict Persistent Symptoms, Journal of the American Medical Association, CDC guidelines to prevent the spread of COVID-19. "As an individual, you have your blood typethere's nothing you can do about it.". Newborn screening tests in the United States dont specifically check for thalassemia trait. People with thalassemia should assume that they are as likely to become infected as the general population and are more likely to have severe outcomes. Quite a bit of research has been published about blood type and COVID-19 risk. The COVID-19 pandemic has led to blood bank shortages, which have created challenges for people with transfusion-dependent thalassemia. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. States with religious and philosophical exemptions from school immunization requirements. People with the intermedia or major forms of the disease have HBB mutations from both parents. Folic acid can help red blood cells develop. WHO COVID19 Dashboard. Learn more about beta-thalassemia trait and pregnancy. (2022). Anemia can affect your weight, whether due to its impact on your appetite and activity levels or its underlying cause. They often share similar symptoms but have different causes as well as different treatments and severity. Some people with thalassemia have cardiomyopathy (heart muscle disease). Needs T, et al. EHA and TIF on How COVID-19 Affects Thalassemia and SCD Patients Telehealth visits, which are appointments with a healthcare provider using electronic devices from your home, are considered the equivalent of an in-person visit in many ways and can provide excellent care in many situations. There are many types of thalassemia. They result in low hemoglobin production and destruction of red blood cells. A second dose of Pfizer or Moderna at least 4 weeks after 1st dose, less susceptibility to developing COVID-19, fewer intensive care unit (ICU) admissions, higher susceptibility to dying from COVID-19, surgery to remove your spleen or gallbladder. Summary document for interim clinical considerations for use of COVID-19 vaccines currently authorized or approved in the United States. Aim: Low levels of immune-related micronutrients have been identified in -thalassemia samples. This site needs JavaScript to work properly. Learn what having thalassemia may mean for you during the COVID-19 pandemic. Li L, et al. Thalassemia is an inherited blood disorder that affects your body's ability to produce hemoglobin and healthy red blood cells. doi: 10.1634/theoncologist.2020-0213. De Sanctis V, Canatan D, Corrons JLV, et al. S124: Adverse events following COVID-19 vaccination in transfusion-dependent thalassemia patients. In thalassemia, the body is unable to make either alpha or beta chains in adequate amounts. Moreover, the excess amount of iron, contributing to oxidative stress in the pathogenesis of the disease, alters the immune system in -thalassemia, which is important during the COVID-19 pandemic.
Holland Public Schools Salary Schedule,
10 Benefits Of Rhythmic Activities,
Denbies Cancellation Policy,
First Mass In Canada Was Celebrated On This Peninsula,
Robert Big Bob'' Morris Cause Of Death,
Articles T
