EHA Endorsement of ESMO Clinical Practice Guidelines for Dia - LWW 2018 Oct 1;29(Suppl 4):iv260. The cumulative incidence of severe carboplatin-related hypersensitivity was 1% after 15 cycles and 2% after 24 cycles, with a plateau beyond this cycle number, and 1% at >7,500 mg and 2% at >12,500 mg, with a plateau beyond this dose (Figures 1A,B ). Management of uncommon chemotherapy-induced emergencies. The BRCA status of our patients was not available for further analysis in this retrospective study. A total of 412 (56.1%) patients experienced spontaneous menopause, 295 (40.1%) surgical menopause, and 28 (3.8%) had preserved fertility. To assist those using and/or evaluating the ESMO Guidelines, download the methodology here, Download the new version of our App with the latest Pocket Guidelines for oncology professionals. Cancer. 57 . Cancer. 2022 Apr 26;14(4):e24515. (2003). Necessary cookies enable core functionality. B., Phillips, P. C., Kang, T. I., et al. J. Clin. Similarly, a Japanese study found that carboplatin hypersensitivity occurred at a median of 11.5 cycles and 8,084.5 mg (Koshiba et al., 2009). (2005) reported that all carboplatin-associated hypersensitivity reactions occur in patients with prior carboplatin exposure, and Tamiya et al. For salvage chemotherapy in the case of recurrent disease, we administered chemotherapeutic regimens including carboplatin with paclitaxel, gemcitabine, or liposomal doxorubicin. 2022 Mar 30;9(4):26. doi: 10.3390/medicines9040026. ESMO Virtual Congress 2020 | OncologyPRO Hypersensitivity to antineoplastic agents. Clinical analysis of thirteen cases of hypersensitivity reactions to carboplatin. 28, 33233329. Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. Oncol. official website and that any information you provide is encrypted Critical revision: C-AC. Up to 16% of patients with ovarian cancer who undergo treatment with carboplatin-containing regimens experience carboplatin-related hypersensitivity (Markman et al., 1999; Polyzos et al., 2001; Sliesoraitis and Chikhale, 2005). 'Allergy' is a hypersensitivity reaction (HSR) initiated by specic immunolo- gical mechanisms. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. With a lower carboplatin infusion rate and pre-treatment with anti-allergy drugs, all of these patients were able to tolerate re-treatment with carboplatin, although 48 (78.7%) of these 61 patients developed hypersensitivity again despite the desensitization protocol. Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies. The results of the trial could answer whether carboplatin hypersensitivity patients have similar chemo-responses in non-platinum regimens without compromising the efficacy of the antineoplastic regimens of these patients. Algorithm for the evaluation of drug hypersensitivity reactions and the role of desensitization for the re-introduction of the first-line medications, when no alternative is available or the alternative does not provide the same benefits or life expectancy as the first line. Platinum desensitization in patients with carboplatin hypersensitivity: a single-institution retrospective study. Information for media including press accreditation. Ann Oncol. Patients feel psycho-social impact of chemo m | EurekAlert! Int J Mol Sci. A., Raja, F. A., Fotopoulou, C., Gonzalez-Martin, A., Colombo, N., Sessa, C., et al. Ovarian cancer is the leading cause of death from gynecological malignancies (Chiang et al., 2013), with a 5-year survival rate of 46% in the United States (92% when localized, 73% with regional metastases, and 28% with distant metastases) (Siegel et al., 2016). Monitor. Leuk Lymphoma. We retrieved clinical information, including age, menopausal status, cancer stage, surgical findings, chemotherapeutic treatment history, recurrence status, and survivorship, from the clinical and operative notes and discharge summaries stored in a centralized database. Accessibility Open. 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Cancer 20, 385393. Multivariate analyses of clinical parameters for carboplatin-related hypersensitivity reactions. doi: 10.1159/000055363, Pujade-Lauraine, E., Wagner, U., Aavall-Lundqvist, E., Gebski, V., Heywood, M., Vasey, P. A., et al. Request PDF | On Jul 13, 2017, Susana Rosell Kernen published Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines | Find, read and cite all the . The rate of hypersensitivity to carboplatin did not differ by patient age, menopausal status, disease entity, receipt of optimal debulking, or the amount of ascites. 19, 460465. doi: 10.1200/JCO.2006.06.0913, Polyzos, A., Tsavaris, N., Kosmas, C., Arnaouti, T., Kalahanis, N., Tsigris, C., et al. These risk factors can help identify patients at greater risk of developing hypersensitivity. National Library of Medicine In an era of deep understanding of the molecular biology underlying the development of cancer, it is crucial that researchers and clinicians exchange knowledge. PH IV/PH FDC SC for HER2-positive BC were well tolerated, with few grade 3 anaphylaxis/hypersensitivity events reported with PH IV and no grade 3 related events with PH FDC SC. BRCA1/2 mutation has been reported to correlate with carboplatin hypersensitivity (Altwerger et al., 2017). Pegylated liposomal doxorubicin and carboplatin compared with paclitaxel and carboplatin for patients with platinum-sensitive ovarian cancer in late relapse. Swain: Financial Interests, Personal, Advisory Role: AstraZeneca; Financial Interests, Personal, Advisory Role: Daiichi Sankyo; Financial Interests, Personal, Advisory Role: F. 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